Why is weight loss after 40 so hard?

Discover revolutionary treatments to help banish your middle-aged bulge

If it feels like losing weight just gets harder and harder, especially once you hit 40, it’s not just you.

While it’s natural for our bodies to undergo changes over time, multiple factors make weight loss more difficult in our middle-aged years.

It’s a struggle to both lose weight AND keep off any pounds you lose. Not to mention that donut that suddenly appears in your midsection and just won’t budge.

At RegenCen, we understand your struggle firsthand. But why does weight loss become such an uphill battle after you hit 40?

Let’s start from the beginning…

Most people notice excess weight creep up like an unwelcome companion sometime in their mid 30s.

Then your 40s hit, and that weight seems to settles in for the long haul. Wrapping itself around your curves, tightening the fabric of your clothes and reminding you of its presence with every step you take.

Simple activities that were once effortless — like a morning stroll — take so much more effort as the added weight pulls you down and weakens your energy.

In your younger years, you could conquer diets with superhero-like strength. Crash diets, trendy cleanses, and even a week of intense exercise could work wonders, magically melting away those stubborn pounds.

But now — in middle age — you find that those very same methods that once worked so well don’t give you the same results, and you can’t help but wonder why.

The answer lies within your body’s hormonal changes, metabolic slowdown, and the pitfalls of unsustainable weight loss programs —  to name just a few.

What factors contribute to my middle-aged weight gain?

Several factors contribute to aging-related weight gain:

  • Hormonal changes
  • Slowing metabolism
  • Unsustainable crash diets
  • Psychological factors, including emotional eating and binging
  • Mobility issues that limit physical activity

Hormonal Changes

Hormones are a major contributing factor to over-40 weight gain. drop, particularly estrogen and progesterone in women, and testosterone in men. These changes disrupt metabolism and increase fat storage.

Metabolic Slowdown

Another challenge in middle-age is a reduced metabolism. As we get older, our metabolic rate naturally decreases, which means our bodies burn calories at a slower pace. It’s not just hormones causing the slowdown – reduced amounts of NAD, glycine, cysteine, and others make it harder to use up stored fat.

This reduced calorie burn makes it harder to create a calorie deficit necessary for weight loss. Combined with hormonal changes, a sluggish metabolism can be a significant — and frustrating — obstacle on your weight loss journey

Unsustainable Previous Weight Loss Programs

Many of us have tried various weight loss programs in the past, only to regain the lost weight shortly after stopping them. This yo-yo effect often occurs because these programs are not designed for long-term sustainability.

Crash diets and extreme calorie restrictions might have worked in your 20s, but as you age, the impact on your body, including increased stress hormones like cortisol, becomes more pronounced.

It’s crucial to adopt a balanced, sustainable approach to weight loss at any age, but especially in your 40s, 50s, and beyond.

Psychological Factors

Years of food restriction, rigid exercise programs and deprivation take a psychological toll and make weight loss after 40 even tougher. Decades of feeling deprived can eventually trigger behaviors like binge eating.

Once you fall off the horse, it may derail any progress you’ve made and make it harder to get back on track. It’s important to maintain a healthy and flexible mindset when approaching weight loss to avoid these complications.

Mobility Issues

As we age, our tendons and joints age, too. Years of wear and tear can result in pain and reduced mobility. These physical limitations might prevent us from engaging in regular physical activity, which in turn reduces the number of calories we burn.

However, exercise is a crucial component of weight loss. Finding ways to address these mobility issues and improve joint health is essential for achieving successful long-term weight loss.


With aging, joint pain in your shoulders, knees, and hands can be unbearable.


So what’s the answer? How do you lose the weight AND keep it off as you age?

While a sustainable, balanced diet is crucial to losing weight and keeping it off as you age, there are also innovative treatments at RegenCen that give you extra support and may help offset age-related causes of weight gain.

Revolutionary Treatments to Banish Your Middle-Aged Bulge

Banish that middle-aged bulge and get long-lasting results with weight loss treatments that help optimize hormones, boost metabolism, support cellular function and empower you to move more like you used to in your 20s. Here’s an overview of some new techniques to manage weight that we offer at our regenerative medicine clinics in Petoskey and Traverse City.


Unlike semaglutide injections, Rybelsus is a pill version of semaglutide that can help with weight loss. Semaglutide works by regulating appetite and reducing food cravings. When combined with a healthy diet and exercise, Rybelsus can be an effective tool in achieving sustainable weight loss.

Intramuscular (IM) Injections with Skinny Shot + and NAD+

Skinny Shot+ is a specially formulated injection that contains essential nutrients, amino acids, and other naturally occurring supplements that help us with the fat-burning process necessary to successful weight loss. As mentioned above, age depletes our bodies of certain specific nutrients, and replacing them can make a big difference in the effectiveness of your diet and exercise program. Patients at RegenCen report the Skinny Shot+ suppresses their appetite and boosts metabolism and energy, resulting in loss of pounds and inches — and just overall feeling better!

Combined with NAD (nicotinamide adenine dinucleotide), these injections can boost metabolism, increase energy levels, and enhance fat burning. This powerful combination can accelerate weight loss and improve overall body composition.

NAD+ (nicotinamide adenine dinucleotide) NAD+ is necessary for all living cells to function properly. Because NAD+ levels decline with age, the result is unwanted weight gain, visible signs of aging and age-related illnesses. Clinical studies have shown that NAD+ treatments have positive effects on aging and on weight loss.

IV Therapy

Intravenous (IV) drips and infusions can provide a range of benefits for weight loss and overall well-being. IV therapy has 100% absorption rate and is used to replenish hydration, maintain vitamin balance, replace nutrients, and refresh your appearance.

IV therapies are very popular as part of an overall health maintenance program and have regenerative health benefits. These treatments deliver a carefully calibrated mix of nutrients, vitamins, and antioxidants directly into the bloodstream.

PRF Joint Injections

Platelet-rich fibrin therapy (PRF) or platelet-rich plasma (PRP) has the potential to effectively address a wide range of arthritic joints, irritated tendons, and various connective tissues. Medical research shows about 85% success with platelet injection therapy in osteoarthritis. At RegenCen, we see positive responses in nearly every case.

The Mobility Shot is our brand name for PRF injections, and it uses all-natural PRF (the second generation PRP) from your own blood cells to relieve arthritic pain, joint stiffness, chronic tendonitis, bursitis, plantar fasciitis or other soft tissue inflammation.

Why wait to lose the weight?

Picture a life where you wake up energized, your metabolism just feels faster, and you can more easily sustain weight loss. That annoying, stubborn bulge in your middle is gone, and your jeans FIT comfortably!

At RegenCen, carefully administered intramuscular injections and restorative IV therapy work together to optimize your overall well-being. The result? Everything from boosted vitality, to weight loss, to an improvement in your body’s capability to heal itself.

And when it comes to joint health, the remarkable benefits of PRF joint injections can ease discomfort and restore mobility, so you can return to enjoying actives again — like pickleball, tennis, or just a morning walk — with newfound ease.

RegenCen’s revolutionary treatments will not only enhance your daily activities but also unlock a vibrant, rejuvenated version of YOU.

Schedule your complimentary consultation in Traverse City or Petoskey, MI or Naples or Boca Grande by clicking here.